What do they know for certain about Endometriosis?
- Endometriosis is exclusively a hormone problem until an ectopic pregnancy or pelvic congestion, fibroid, polyp or endometriosis are found.
- Retrograde Menses is ignored since Endometriosis is exclusively a hormonal problem.
- The fibroid, polyp or endometriosis are treated exclusively as a hormone problem .
- Solution is hormone treatment until fibroid, polyp or endometriosis can be surgically removed.
- After surgical removal of fibroid, cyst or endometriosis, continues to be treated as exclusively a hormone problem.
Estradiol Promotes Growth of Endometriosis
Endometriosis is an estrogen-dependent disease, which means that it is largely affected by hormonal imbalances. The endometriotic tissue produces its own estradiol-17β, which promotes the growth of the disease and aggravates the symptoms, such as pain. Unlike the healthy uterus lining, endometriotic tissue is deficient in the enzyme that inactivates estradiol-17β to estrone (E1). This deficiency leads to higher levels of estradiol-17β in endometriotic tissues than in the healthy uterine lining.
Who is likely to get Retrograde Menstruation?
Retrograde menstrual bleeding into the peritoneal cavity is the rule rather than the exception in women on peritoneal dialysis and possibly in all menstruating women.1Blumenkrantz MJ, Gallagher N, Bashore RA, Tenckhoff H. Retrograde menstruation in women undergoing chronic peritoneal dialysis. Obstet Gynecol. 1981 May;57(5):667-70. 2Viganò P, Caprara F, Giola F, Di Stefano G, Somigliana E, Vercellini P. Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates. Hum Reprod Open. 2024 Jul 12;2024(3):hoae045. 3Maybin JA, Critchley HO. Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update. 2015 Nov-Dec;21(6):748-61. 4Halme J, Hammond MG, Hulka JF, Raj SG, Talbert LM. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984 Aug;64(2):151-4. Retrograde spill is seen in 97% of those with endometriosis.5D’Hooghe TM, Bambra CS, Suleman MA, Dunselman GA, Evers HL, Koninckx PR. Development of a model of retrograde menstruation in baboons (Papio anubis) Fertility and Sterility. 1994;62(3):635–638. 6Sourial S, Tempest N, Hapangama DK. Theories on the pathogenesis of endometriosis. Int J Reprod Med. 2014;2014:179515. 7Sampson JA. Heterotopic or misplaced endometrial tissue. American Journal of Obstetrics and Gynecology. 1925;10(5):649–664. Blood can be found in the abdominal fluid in >90% of women with healthy fallopian tubes during time of menstruation.8Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Annals of the New York Academy of Sciences. 2008;1127:106–115. 9Koninckx PR, Kennedy SH, Barlow DH. Endometriotic disease: the role of peritoneal fluid. Human Reproduction Update. 1998;4(5):741–751. 10Harirchian P, Gashaw I, Lipskind ST, et al. Lesion kinetics in a non-human primate model of endometriosis. Human Reproduction. 2012;27:2341–2351. It’s a normal part of the menstrual process and usually not a cause for worry. It becomes a problem when it leads to painful symptoms or a condition like endometriosis.
Do you bleed with Retrograde Menstruation?
Yes. Women with retrograde menstruation still bleed from their vagina, but some of the bleeding flows in the wrong direction. Instead of coming out your vagina, the blood flows upward through your fallopian tubes and into your abdominal and pelvic cavity. The cells can then grow superficially on the peritoneum (the lining of your abdominal wall that covers your stomach, spleen, intestines and other abdominal organs), or deeper into the abdominal or pelvic organs.
Appendix Cleans Up Retrograde Menses
The Appendix is made up of one way valves. making it a lymphatic sump pump. The learned ones view the appendix as a vestigial mistake, or more recently a bacterial safe house and for far too many a payment for a boat or vacation home.
Think of the appendix as a tethered pool cleaner or Rhoomba; capable of sweeping around the pelvic bowl. Vacuuming fluids (retrograde menses, fluids from intestines), and debris (endometrial clots, bacteria), from the abdominal compartment.
Lab Analysis, Consultation, DUTCH Complete – DUTCH Adrenal + DUTCH Sex Hormone Metabolites + OATs
References
- 1Blumenkrantz MJ, Gallagher N, Bashore RA, Tenckhoff H. Retrograde menstruation in women undergoing chronic peritoneal dialysis. Obstet Gynecol. 1981 May;57(5):667-70.
- 2Viganò P, Caprara F, Giola F, Di Stefano G, Somigliana E, Vercellini P. Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates. Hum Reprod Open. 2024 Jul 12;2024(3):hoae045.
- 3Maybin JA, Critchley HO. Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update. 2015 Nov-Dec;21(6):748-61.
- 4Halme J, Hammond MG, Hulka JF, Raj SG, Talbert LM. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984 Aug;64(2):151-4.
- 5D’Hooghe TM, Bambra CS, Suleman MA, Dunselman GA, Evers HL, Koninckx PR. Development of a model of retrograde menstruation in baboons (Papio anubis) Fertility and Sterility. 1994;62(3):635–638.
- 6Sourial S, Tempest N, Hapangama DK. Theories on the pathogenesis of endometriosis. Int J Reprod Med. 2014;2014:179515.
- 7Sampson JA. Heterotopic or misplaced endometrial tissue. American Journal of Obstetrics and Gynecology. 1925;10(5):649–664.
- 8Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Annals of the New York Academy of Sciences. 2008;1127:106–115.
- 9Koninckx PR, Kennedy SH, Barlow DH. Endometriotic disease: the role of peritoneal fluid. Human Reproduction Update. 1998;4(5):741–751.
- 10Harirchian P, Gashaw I, Lipskind ST, et al. Lesion kinetics in a non-human primate model of endometriosis. Human Reproduction. 2012;27:2341–2351.
