Explore Adrenal Stress Index Zone 2 – Stress adapted with a divergence in response to ACTH, signifying the transition from the alarm reaction to the resistance stage. Understand how DHEA levels are shifting into cortisol production, indicating the body’s adaptation to stress. Learn why support is essential at this stage to prevent further progression into the resistance stage and preserve optimal adrenal function. Take proactive measures to maintain balance and support adrenal health.
Zone 2. Stress adapted with a divergence in response to ACTH
This stage indicates further progression of the alarm reaction into the resistance stage. The DHEA levels are no longer elevated because they are shifting into cortisol. The body is no longer in acute stress, however, it is still in the early alarm reaction. These patterns need to be supported to avoid further progression into the resistance stage in which DHEA levels will become compromised.
Recommendation for Supplementation:
1. Glysen (K-1):
2. Protoglysen (K-28)
3. Adaptacrine (K-2):
4. Adrenacalm cream (K-16):
5. Omega CO-3 (K-7):
Phase 1. Restoration Plan
Adrenal Stress Index
A. Use Cortisol/DHEA ratios to guide treatment.
i. Stay on protocol until next test, monitor progress of protocol at 30 day intervals with MAF.
ii. If there is improvement in Cortisol/DHEA Zone on the ASI, alter supplementation protocol to new zone.
iii. If there is little or no change remain on protocol until there is a change in their symptoms, either expressed verbally or noted on MAF.
iv. If there is concurrent depressed SIgA levels and Insulin Resistance consider completing the ClearVite GI Protocol.
Adrenal Deal Breaker
Anemia
If you are anemic. You should order Bio-Screen Sustain Max to determine which type of anemia causing your symptoms.
It is very difficult to improve adrenal/blood sugar patterns if the patient is anemic. Your Red blood Cells will not be able to deliver oxygen to mitochondria for ATP production and will be dependent upon glycolosis for energy production. Glycolosis is very inefficient and places great demands upon the blood sugar/adrenal stabilizing system.
Inflammation/Unresolving Immune Response
If your anemia is due to inflammation and/or bacterial infection use of iron supplements will increase bacterial growth, free radical production and an unresolving immune response. Do Not Use Iron Supplements in presence of inflammation.
Adrenal Zone 2 Support Products

Apex Energetics Glysen K-2
$32.98 – $51.98
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This product has multiple variants. The options may be chosen on the product page

Apex Energetics Glysen-Synergy K-79
$89.98
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Apex Energetics Adaptacrine K-2
$39.98 – $45.98
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This product has multiple variants. The options may be chosen on the product page

Apex Energetics AdrenaCalm KR-16
$45.98
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This product has multiple variants. The options may be chosen on the product page

Apex Energetics OmegaCo-3 16 oz. K-7
$27.98
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Apex Energetics OmegaCo-3-SE K-113 90 Softgel
$36.98
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Apex Energetics Protoglysen K-28
$38.50
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Apex Energetics Brain-E DHA 4oz. K-53
$56.98
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Apex Energetics Phyto Brain-E 4oz. K-54
$85.79
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Apex Energetics Phyto Brain-E XL 8oz. K-123
$157.79
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Adrenal Stress Index Zones:
- Adrenal Stress Index Optimal Zone
- Adrenal Stress Index Zone 1
- Adrenal Stress Index Zone 2
- Adrenal Stress Index Zone 3
- Adrenal Stress Index Zone 4
- Adrenal Stress Index Zone 5
- Adrenal Stress Index Zone 6
- Adrenal Stress Index Zone 7
Related Keywords:
- Cortisol levels
- Adrenal fatigue
- Adrenal gland function
- Stress and adrenal health
- Adrenal support supplements
- hpt axis
- hypothalamic pituitary adrenal axis
- adrenal stress index
Top Competitor Sites with URLs:
- Healthline – https://www.healthline.com/
- Mayo Clinic – https://www.mayoclinic.org/
- WebMD – https://www.webmd.com/
Suggested Sites for Outreach and Backlinks:
- Harvard Health Publishing – https://www.health.harvard.edu/
- National Institutes of Health (NIH) – https://www.nih.gov/
- American Institute of Stress – https://www.stress.org/