Quick Summary of Melatonin Effects on the Body
- Visible light decreases Melatonin levels.
- Darkness increases Melatonin levels.
- Blue Blocker Glasses increases Melatonin levels.
- Isolation in Dark Room Increases Melatonin levels.
- Causing Increased Th17 cytokines provoking immune cells.
- Th17 is involved in immune and tissue inflammatory responses.
- Th17 cytokines can also cause tissue pathologies.
- Th17 cells are heavily implicated in autoimmune diseases.
- Th17 cells can secreting immune factors, such as IL-10, which causes Anaphylactic Shock.
- Melatonin is produced in multiple organs in the body.
- Naturally occurring Melatonin increases Autoimmune cytokine storms and flairs during the Fall and Winter months.
- Wearing Blue Blocker Glasses increases the amount of naturally produced Melatonin.
- Melatonin lowers Thyroid Stimulating Hormone (TSH).
- Melatonin Increases Polycystic Ovarian Syndrome (PCOS).
- Melatonin increases the Th1, Th2 immune response response to antibodies.
- Melatonin increases Th17 immune response
- Melatonin increases parasite reproduction.
Ovulation Pain Support
It is becoming clear that melatonin acts directly on the ovaries.1Cruz, M.H.; Leal, C.L.; Cruz, J.F.; Tan, D.X.; Reiter, R.J. Essential actions of melatonin in protecting the ovary from oxidative damage. Theriogenology 2014, 82, 925–932. It is known that, compared to other organs, the accumulation of melatonin is highest in the ovaries.2Wurtman, R.J.; Axelrod, J.; Potter, L.T. The uptake of H3-melatonin in endocrine and nervous tissues and the effects of constant light exposure. J. Pharmacol. Exp. Ther. 1964, 143, 314–318. Melatonin also is found at a high concentrations in human follicular fluid, and it increases in proportion to follicular growth.3Nakamura, Y.; Tamura, H.; Takayama, H.; Kato, H. Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil. Steril. 2003, 80, 1012–1016. Hence, there is a mechanism whereby melatonin is produced in the follicles as they enlarge. Since ovulation is perceived as a phenomenon that resembles inflammation, and as a defense mechanism against ROS generated in follicles, antioxidative enzymes and antioxidants, including melatonin, protect oocytes and granulosa cells from oxidative damage.4Tamura H, Jozaki M, Tanabe M, Shirafuta Y, Mihara Y, Shinagawa M, Tamura I, Maekawa R, Sato S, Taketani T, Takasaki A, Reiter RJ, Sugino N. Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. Int J Mol Sci. 2020 Feb 8;21(3):1135.
Melatonin Surge Reduction Support
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References
- 1Cruz, M.H.; Leal, C.L.; Cruz, J.F.; Tan, D.X.; Reiter, R.J. Essential actions of melatonin in protecting the ovary from oxidative damage. Theriogenology 2014, 82, 925–932.
- 2Wurtman, R.J.; Axelrod, J.; Potter, L.T. The uptake of H3-melatonin in endocrine and nervous tissues and the effects of constant light exposure. J. Pharmacol. Exp. Ther. 1964, 143, 314–318.
- 3Nakamura, Y.; Tamura, H.; Takayama, H.; Kato, H. Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil. Steril. 2003, 80, 1012–1016.
- 4Tamura H, Jozaki M, Tanabe M, Shirafuta Y, Mihara Y, Shinagawa M, Tamura I, Maekawa R, Sato S, Taketani T, Takasaki A, Reiter RJ, Sugino N. Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. Int J Mol Sci. 2020 Feb 8;21(3):1135.
