Endometriosis Starts with Retrograde Menses

Retrograde menstruation occurs when endometrial cells are refluxed through the fallopian tubes during menstruation and implant onto the cavity of the abdomen or pelvic organs. Since retrograde menstruation is a very common phenomenon among women of reproductive age, there must be other factors that may contribute to the onset and growth of endometriosis.

Retrograde Menstruation

Retrograde spill is seen in 97% of women with endometriosis. A significant association is found between endometriosis and fallopian tube damage not due to endometriosis, such as adhesions. Retrograde menstruation through the fallopian tubes into the abdominal cavity is a very common event in all menstruating women with open fallopian tubes. Blood can be found in the peritoneal fluid in greater than 90% of women with healthy fallopian tubes during time of menstruation.

Does the body have a way to clean up Retrograde Menses?

Understanding the Lymphatics is Key to Understanding the Appendix


Appendix Cleans Up Retrograde Menses

The Appendix is made up of one way valves. making it a lymphatic sump pump. The learned ones view the appendix as a vestigial mistake, or more recently a bacterial safe house and for far too many a payment for a boat or vacation home. If the Appendix is a “bacterial safe house”? Then Polyps should be considered Bacterial Safe Houses. How often do you learn of someone having polyps removed?

The Appendix
“Its major importance would appear to be financial support of the surgical profession.”

Alfred Sherwood Romer and Thomas S. Parsons The Vertebrate Body (1986), p. 389.

Think of the appendix as a tethered pool cleaner or Rhoomba; capable of sweeping around the pelvic bowl. Vacuuming fluids (retrograde menses, fluids from intestines), and debris (endometrial clots, bacteria), from the abdominal compartment.

Much is unknown about the function of the appendix. What is known and overlooked by the medical community is that it is composed of lymphoid tissue with valve like structures facilitating one way movement of fluid into the colon. It is located at a lowest point in the abdominal cavity.

The wall of the appendix is composed of all layers typical of the intestine, but it is thickened and contains a concentration of lymphoid tissue. Similar to the tonsils, the lymphatic tissue in the appendix is typically in a constant state of active immune response, and it is generally difficult to tell the difference between pathological disease and the “normal” condition.

Appendicitis may be caused by endometrial tissue blocking the central cavity of the appendix. Young girls with an intact hymen often have their appendix removed due to retrograde menses.

It is well known that Endometriosis clogging up the appendix can mimic the presentation of acute appendicitis. Symptoms are characterized as nausea, vomiting, abdominal pain which migrates to the right lower quadrant. Physical findings include right lower quadrant tenderness and rebound in the face of a low grade fever.,

Retrograde menstruation involves the direct-contact deposition of endometrial tissue into the abdominal cavity. Retrograde menstruation leads to endometrial tissue seeding directly onto structures nearby the uterus.

The endometrial tissue can deposit on both the appendix and the cecum. This abnormal endometrial tissue can progress to acute appendicitis with chronic inflammation caused by the endometrial glands and stroma, causing the development of fibrous adhesions and enlargement of the appendix and can wholly or partially block the appendiceal lumen.,


Endometriosis is an estrogen-dependent disease. Estrogen(s) is the most important known factor that stimulates the growth of Endometriosis. Estrogen(s) delivery to endometriotic implants was classically viewed to be only via the circulating blood in an endocrine fashion.

It is now known that Endometriotic tissues develop blood supply through angiogenesis (growth of new blood vessels). Endometriotic implants continuously produce Estradiol and prostaglandin (PG)E2 in the endometriotic cells in an autocrine positive feedback manner.

For too many Doctors, the HPA Axis is the only HP Axis in existence. Studies about thyroid, ovaries and/or uterus, only reference the HPA Axis.

What most fail to recognize is that Endometriosis produces Estradiol-17β in an Autocrine and Paracrine manner. Autocrine production of Estradiol-17β within the Endometriosis stimulating it to grow. After a time, the body begins to view the Endometriosis as part of the body, growing new blood vessels (angiogenesis) to supply the living Endometriosis tissue with blood containing oxygen, glucose, nutrients and hormones. Paracrine production of Estradiol-17β build more Endometriotic growth. The angiogenic connection starts contributing more Estradiol-17β to the uterus, and ovaries independently of any feedback control by the Hypothalamic-Pituitary-Gonadal Axis (HPG). This further disrupts the function of the uterus and ovaries creating untold problems considered to be exclusively a hormonal problem. Believed to be correctable only by more Estradiol Hormone Replacement Therapy. Are you recognizing there might be a problem?

This response is accompanied by angiogenesis, adhesions, fibrosis, scarring, neuronal infiltration, and anatomical distortion, resulting in pain and infertility.,,, Although most women have retrograde menstruation, not all women with retrograde menstruation have endometriosis; affected women may have an Portal Hypertension dysfunction that interferes with clearing of the lesions.,

Endometriotic tissue produces Estradiol, independent of HPG Axis control. Estradiol promotes growth of Endometriosis.

Estradiol (E2) Worsens Endometriosis

The biologically active estrogen, estradiol, aggravates the pathological processes (e.g., provoking a resolving immune response and endometriosis growth) and the symptoms (e.g., pain) associated with endometriosis. Abundant quantities of estradiol are available within endometriotic tissue via several mechanisms including Autocrine, Paracrine and local aromatase production.

The symptomatology of the endometriosis is often related to the location of the lesions, and for that reason endometriosis of the gastrointestinal tract, may cause a wide spectrum of symptoms.,, Endometriosis not only may cause symptoms of acute appendicitis,,, but also is known to cause cyclic and chronic right lower quadrant pain, dark sticky feces, lower intestinal hemorrhage, cecal intussusceptions, and intestinal perforation, especially during pregnancy.,

Portal Hypertensions Influence on Endometriosis

Portal Hypertension is influenced by the complex interaction between vascular resistance in the liver (fatty liver from insulin resistance), angiogenesis of collateral vessels, increased plasma volume,, and the amount of portal blood flow, which varies considerably between individuals. Once a certain pressure threshold is reached, collaterals form, and the correlation between the ultrasonographic parameters and Portal Hypertension becomes limited. Difficult to identify, even if they are looking for it.

Portal Hypertension make Lymphatics stagnant decreasing ability to absorb Retrograde Menses.

Hepatic Portal Hypertension (HPH) is a multi-organ condition. Portal hypertension induces the formation of portal-systemic collaterals and multiple-organ-dysfunction syndrome (MODS) complications. Mesenteric angiogenesis plays an important role in increasing splanchnic blood inflow and formation of portal-systemic collateral vascular system.

Angiogenesis is the growth of blood vessels from the existing vasculature. It occurs throughout life in both health and disease, beginning in utero and continuing on through old age. Angiogenesis occurs in the female reproductive system during the monthly menstrual cycle. Normal angiogenesis also occurs as part of the body’s repair process, such as in the healing of wounds and fractures. On the other hand, uncontrolled angiogenesis contributes to a wide variety of serious diseases.

The female reproductive organs (ovary, uterus, and placenta) are some of the few adult tissues that exhibit regular intervals of rapid growth of blood vessels. They also are highly vascular and have high rates of blood flow. Angiogenesis, or vascular growth, is therefore an important component of the growth and function of these tissues.

Angiogenesis (the growth of new blood vessels from pre-existing vasculature) occurs with the growth and regression of the uterine lining to provide an uninterrupted blood supply to this rapidly changing tissue. Endometrial angiogenesis is under the overall control of the ovarian steroids Estrogen(s) and Progesterone.,,,

I know your Doctor checks your “Estrogen” levels. Which one would that be?

A variety of pathologies of the female reproductive organs are associated with disturbances of the angiogenic process, including dysfunctional uterine bleeding, endometrial hyperplasia and carcinoma, endometriosis, failed implantation and subnormal fetal growth, myometrial fibroids (uterine leiomyomas) and adenomyosis, ovarian hyperstimulation syndrome, ovarian carcinoma, and polycystic ovary syndrome (PCOS).

Do You Need Help?

Portal Hypertension is a Multi-Organ condition. It is not as simple as “here-take-this-supplement”. You need help from someone that understands this multi-organ condition and not focused on the latest fad diagnosis. HyrSelf Veins ReDux was specifically formulated to support the reduction of fluid buildup in Portal Hypertension. You need a Second Opinion, if you have been dealing with Endometriosis for any length of time. Especially, if you have been taking Hormone Replacement Estrogens, unknowingly supporting the growth of Endometriosis.